Feldbrügge lab

The Feldbrügge lab is using in vivo approaches to study mRNA transport and local translation. We focus on the tight coupling between mRNA and membrane trafficking using endosomal long-distance transport along microtubules as an example.

Within the FOR2333 Research Unit we study:

In close collaboration with the König and Zarnack lab, we investigate how the key RNA-binding protein Rrm4 coordinates translation and transport of cargo mRNAs. To this end we focus on the precise binding behaviour of Rrm4 at landmark sites of translation mediated by the concerted action of its three RRM domains.

Michael Feldbrügge is Co-Speaker of the FOR2333 Research Unit.

Selected publications by the Feldbrügge lab:

• Müntjes et al. EMBO Rep 22, e52445 (2021) [pubmed]
• Jankowski et al. EMBO Rep 24: e47381 (2019) [pubmed]
• Béthune et al. Trends Cell Biol. 29: 178-188 (2019) [pubmed]
• Olgeiser et al. EMBO Rep. 20: e46588 (2019) [pubmed]
• Pohlmann et al. eLife 4: 10.7554/eLife.06041 (2015) [pubmed]