The Jansen lab is studying the function of ribonucleoprotein particles (RNPs), using biotin proximity labeling as a novel approach. We characterize the associated proteome of specific mRNAs, especially those that become localized. Knowledge on the proteome will help to understand the biology of mRNAs (transport, translation, decay), especially in the context of mRNPs. We combine proximity labeling with biochemistry and live imaging techniques in order to understand how RNP complexes assemble and disassemble.
Within the FOR2333 Research Unit we study:
a. The function of novel RNA-binding proteins during the localization of ß-actin mRNA in fibroblasts
b. The common and specific proteomes of localized mRNPs in migrating cell types
c. The associating proteome of ß-actin mRNA in developing neurites (collaboration with Chekulaeva lab)
Prof. Dr. Ralf-Peter Jansen
Interfaculty Institute of Biochemistry, University of Tübingen
Website at University of Tuebingen