Jansen lab

The Jansen lab is studying the function of ribonucleoprotein particles (RNPs), using biotin proximity labeling as a novel approach. We characterize the associated proteome of specific mRNAs, especially those that become localized. Knowledge on the proteome will help to understand the biology of mRNAs (transport, translation, decay), especially in the context of mRNPs. We combine proximity labeling with biochemistry and live imaging techniques in order to understand how RNP complexes assemble and disassemble.

Within the FOR2333 Research Unit we study:

a. The function of novel RNA-binding proteins during the localization of ß-actin mRNA in fibroblasts

b. The common and specific proteomes of localized mRNPs in migrating cell types

c. The associating proteome of ß-actin mRNA in developing neurites (collaboration with Chekulaeva lab)

Selected publications by the Jansen lab:

• Singer-Krüger et al. FEBS J (2019); doi: 10.1111/febs.15007
• Mukherjee et al. PNAS 116: 12863-12872 (2019); doi: 10.1073/pnas.1820737116
• Bethune et al. Trends Cell Biol 29: 178-188 (2018); doi: 10.1016/j.tcb.2018.10.005
• Syed et al. FEBS Lett 592: 1870-1881 (2018); doi: 10.1002/1873-3468.13098
• Cheng et al. Cell Rep 24: 20-26 (2018); doi: 10.1016/j.celrep.2018.06.015