Mandy Jeske
The Jeske lab employs a highly interdisciplinary approach combining RNA and protein biochemistry with X-ray crystallography and Drosophila genetics to unravel molecular mechanisms that are key to germline function and early embryonic development. The lab focusses on understanding specific aspects of the piRNA pathway as well as on translation control of developmentally significant mRNAs.
Selected publications by the Jeske lab:
- Jeske, M., Müller, C.W., Ephrussi, A. (2017). The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Genes Dev. 31(9), 939-952.
- Jeske, M., Bordi, M., Glatt, S., Müller, S., Rybin, V., Müller, C.W., Ephrussi, A. (2015). The crystal structure of the Drosophila germline-inducer Oskar identifies two domains with distinct Vasa helicase- and RNA-binding activities. Cell Rep. 12(4), 587-98.
- Jeske, M., Moritz, B., Anders, A., Wahle, E. (2011). Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. EMBO J. 30(1), 90-103.
- Jeske, M., Wahle, E. (2008). Cell-free deadenylation assays with Drosophila embryo extracts. Meth. Enzymol. 448, 107-118.
- Jeske, M., Meyer, S., Temme, C., Freudenreich, D., Wahle, E. (2006). Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos. J. Biol. Chem. 281(35), 25124-25133.
