The Niessing lab mainly uses X-ray crystallography and biochemistry to understand mechanistic principles of RNA-mediated gene regulation in eukaryotes. Besides mRNA localization, a main focus is on translational control.
We participate in the FOR2333 Research Unit with two projects:
Project 1: Together with the Jansen, König and Zarnack labs, we use the model system budding yeast to understand what defines a zip-code element and how translational control is achieved on the ASH1 mRNA.
Project 2: We wish to study neuronal mRNA transport by focussing on the specificity of RNA binding proteins such as Drosophila and mouse Staufen proteins and their interplay with co-factors. For this project we collaborate with the Ephrussi, Jansen, König and Zarnack labs.
Dierk Niessing serves as Speaker of the FOR2333 Research Unit.
(* shared corresponding authorship)