Niessing lab

The Niessing lab mainly uses X-ray crystallography and biochemistry to understand mechanistic principles of RNA-mediated gene regulation in eukaryotes. Besides mRNA localization, a main focus is on translational control.

We participate in the FOR2333 Research Unit with two projects:

Project 1: Together with the Jansen, König and Zarnack labs, we use the model system budding yeast to understand what defines a zip-code element and how translational control is achieved on the ASH1 mRNA.

Project 2: We wish to study neuronal mRNA transport by focussing on the specificity of RNA binding proteins such as Drosophila and mouse Staufen proteins and their interplay with co-factors. For this project we collaborate with the Ephrussi, Jansen, König and Zarnack labs.

Dierk Niessing serves as Speaker of the FOR2333 Research Unit.

Selected publications by the Niessing lab:

• Heber et al. Nature Commun (2019) [pubmed]
• Rehage et al. Nature Commun (2018)* [pubmed]
• Edelmann et al. Nature Struct Mol Biol (2017) [pubmed]
• Janowski et al. Nature Commun (2016)* [pubmed]
• Schlundt et al. Nature Struct Mol Biol (2014)* [pubmed]

(* shared corresponding authorship)